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Chemicals analysis

In the Biochemistry laboratory, chemical, physical and biochemical tests are performed in order to evaluate the structural and efficiency properties of molecules and enzymes, such as products containing hyaluronic acid.

SEM analysis

SEM analisi

Analysis in Scanning Electron Microscopy (SEM) of the surface of a substance or on a surface treated with the substance. The protocol allow to study the morphological features of compounds (i.e. powders, gels, formulations) or the capability to create layers.


Market: Cosmetics, Medical devices, Raw materials. 

TEM analysis

tem analisi

Analysis in Transmission Electron Microscopy (TEM) can be used to study the structure of organic substances, i.e. the collagen’s triple-stranded helical molecule contained in raw materials or formulations.



Market: Cosmetics, Medical devices, Raw materials.

Ultrastructural analysis

The ultrastructural study of a sample is a multiparametric analysis performed by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM), which provides a first morphological analysis with photos at different magnifications and then the structure of the substance to be tested.



Market: Cosmetics, Medical devices, Raw materials.


Heavy metals analysis

metalli pesanti

This analysis provides the identification of the possible presence, in a raw material or in a finished product, of the most common heavy metals: As, Cd, Cr, Co, Ni, Pb, Hg, Sb, by the Inductively coupled plasma – optical emission spectrometry technique (ICP-OES).




Market: Cosmetics, Medical devices, Raw materials, Household products.

Cannabinoids analysis


Titration of THC, THC-A, CBD, CBD-A, CBN and CBG contents in raw material or in a finished product is performed by high performance liquid chromatography-UV detection (HPLC-UV) coupled with mass spectrometry (MS) techniques.




Market: Cosmetics, Actives, Raw materials.

Determination of HA percentage

Determinazione della percentuale di acido ialuronico

The determination of the amount of hyaluronic acid (HA) inside medical devices, in particular injectable HA hydrogel fillers, is fundamental for the registration of the product to be tested.

The analysis is performed by a protocol developed, set-up and patented by UB-CARE.



Market: Cosmetics, Medical devices, Raw materials.


Identification of chemicals in formulations


The identification of known compounds inside raw materials and finished products has a great importance in terms of certification of the quality of the manufacturing process.

The study is performed by 13C NMR solid-state spectroscopy. The analysis allow to verify also the grade of the ingredients, highlighting possible contaminants.

This analysis is able to identify a known compound, used as a standard, inside a formulation, certifying its real presence.

Market: Cosmetics, Medical devices, Raw materials.

Sensitivity to hyaluronidase


In aesthetic medicine, hyaluronidases are used for dissolving the injected hyaluronic acid filler, eliminating nodules, correcting the injection of excessive quantities of injected filler, or avoiding ischemic complications derived from this practice.
The product containing hyaluronic acid is put into contact with the hyaluronidase enzyme and the N-acetylglucosamine release in the sample, as a function of the product’s degradation, is assayed by a time-course analysis to reach the maximum degradation rate.The aim of the test is the determination of the degradation percentage of hyaluronic acid by the quantification of N-acetylglucosamine released by the action of hyaluronidase.

 Market: Medical devices, Raw materials.

Determination of primary aromatic amines

A group of primary aromatic amines is analyzed according to Commission Regulation (EU) No. 10/2011, its amendments and technical guidelines of the CCR EN24815 EN2011.


Market: Medical devices, Raw material.

Determination of molecules and polymers

Caratterizzazione di moelcole e polimeriThe characterization of each product is essential to know its limits and potential. For this reason, our laboratories offer a complete analytical support for a thorough investigation of the chemical and physical characteristics of the substance. Our analyzes cover several areas, including:

– Rheology (viscoelasticity);
– Characterization of the molecular weight and polydispersion index;
– Asset titration;
– Degradation of organic molecules (degradation of hyaluronic acid by hyaluronidase);
– Percentage of hyaluronic acid by means of a patented internal method;
In silico study to predict the effectiveness of a molecule.


Market: Cosmetics, Medical devices, Raw materials.