Skin Ageing

Skin ageing has gained increasing interest, not only because it is the most obvious sign of the ageing process but mostly because it represents a window on human body health, being likely to help in predicting systemic diseases and their outcome, such as chronic metabolic diseases including obesity.

Skin ageing affects our body by extrinsic factors such as UV irradiation, that can lead to benign and malignant skin tumours, and by intrinsic factors like genetic predisposition and changes in endocrine environment, that reflects the degradation processes of the entire organism.The main feature of intrinsic ageing is represented by changes occurring in the extracellular matrix composition, especially in a reduction of the elastic fibre content of the skin.

The project focuses on the study of the intrinsic skin ageing mechanisms, in particular on cell cycle regulation and DNA repair, on fundamental molecules such as elastin and extracellular matrix, and on the effects of different growth factors on this process.