3D model of epidermis

Our goal is to identify a cell system which can be used as a model for tests that are able to satisfy different demands from the cosmetics industry, from anti-aging product to the anti-oxidant or anti- cellulite ones, to exclude the first possible irritant effect of the product itself.

We want to re-create a 3D model of the human epidermis in laboratory, and then analyse the different aspects of a cosmetic product through the study of the mechanisms underlying the development of allergic dermatitis. Fundamental importance in the inflammatory process is covered by the release of cytokines from epithelial cells and for this reason, these cells represent the first target for the irritants and allow to identify as allergen the substance that triggers the cascade of events.